Cerebellar associative sensory learning defects in five mouse autism models

Cerebellar associative sensory learning defects in five mouse autism models

Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2−/−, L7-Tsc1 (L7/Pcp2Cre::Tsc1flox/+), and patDp(15q11-13)/+, we report specific perturbations in de...

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Bibliographic Details
Main Authors: Alexander D Kloth, Aleksandra Badura, Amy Li, Adriana Cherskov, Sara G Connolly, Andrea Giovannucci, M Ali Bangash, Giorgio Grasselli, Olga Peñagarikano, Claire Piochon, Peter T Tsai, Daniel H Geschwind, Christian Hansel, Mustafa Sahin, Toru Takumi, Paul F Worley, Samuel S-H Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
autism spectrum disorder
associative learning
cerebellum
Online Access:https://elifesciences.org/articles/06085

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