Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis

Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis

BackgroundDecompensated cirrhosis patients are more prone to bacterial infections. Myeloid-derived suppressor cells (MDSCs) expand in sepsis patients and disrupt immune cell functions. Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy helps in restoring immune cell functions and reso...

Full description

Bibliographic Details
Main Authors: Rashi Sehgal, Rakhi Maiwall, Vijayaraghavan Rajan, Mojahidul Islam, Sukriti Baweja, Navkiran Kaur, Guresh Kumar, Gayatri Ramakrishna, Shiv K. Sarin, Nirupma Trehanpati
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
sepsis
GM-CSF
Tregs
immune modulation
liver cirrhosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.828949/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.828949/full

Similar Items