Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions

RNA silencing is a novel gene regulatory mechanism that confines the transcript level by either preventing translation or by the initiation of particular RNA degradation. Small interfering RNAs are regularly represented as the exogenously made or viral inducers of RNAi. Such small RNAs have been use...

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Bibliographic Details
Main Authors: Anum Munir, Shumaila Azam, Sahar Aslam, Azhar Mehmood, G. Mujtaba Shah, Saeed Amjad, Muhammad Younis, Sahar Fazal
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Informatics in Medicine Unlocked
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914818300443