Self-propagative replication of Aβ oligomers suggests potential transmissibility in Alzheimer disease.

The aggregation of amyloid-β (Aβ) peptide and its deposition in parts of the brain form the central processes in the etiology of Alzheimer disease (AD). The low-molecular weight oligomers of Aβ aggregates (2 to 30 mers) are known to be the primary neurotoxic agents whose mechanisms of cellular toxic...

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Bibliographic Details
Main Authors: Amit Kumar, Kayla M Pate, Melissa A Moss, Dexter N Dean, Vijayaraghavan Rangachari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4218758?pdf=render