Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

BACKGROUND Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation of lipid peroxidation products acrolein and 4‐hydroxy trans‐2‐nonenal, and the depletion of ATP levels. Cardioprotective interventions, design...

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Bibliographic Details
Main Authors: Jingjing Zhao, Daniel J. Conklin, Yiru Guo, Xiang Zhang, Detlef Obal, Luping Guo, Ganapathy Jagatheesan, Kartik Katragadda, Liqing He, Xinmin Yin, Md Aminul Islam Prodhan, Jasmit Shah, David Hoetker, Amit Kumar, Vijay Kumar, Michael F. Wempe, Aruni Bhatnagar, Shahid P. Baba
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
acrolein
anserine
balenine
carnosine
carnosine synthase
intracellular pH
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.015222

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.015222

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