Population pharmacokinetics of everolimus in patients with seizures associated with focal cortical dysplasia

Population pharmacokinetics of everolimus in patients with seizures associated with focal cortical dysplasia

Background: Everolimus is an inhibitor of mammalian target of rapamycin complex 1. As mutations in TSC1 and TSC2, which cause partial-onset seizures associated with TSC, were found in focal cortical dysplasia type Ⅱ (FCD Ⅱ) patients, a clinical trial has been performed to explore the efficacy and sa...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Jinha Park, Se Hee Kim, Jongsung Hahn, Hoon-Chul Kang, Sang-Guk Lee, Heung Dong Kim, Min Jung Chang
Format: Artykuł
Język:English
Wydane: Frontiers Media S.A. 2023-11-01
Seria:Frontiers in Pharmacology
Hasła przedmiotowe:
everolimus
focal cortical dysplasia
epilepsy
population pharmacokinetics
non-linear mixed-effect modeling
Dostęp online:https://www.frontiersin.org/articles/10.3389/fphar.2023.1197549/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1197549/full

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