Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

The transgenic mouse line PS2APP (PS2N141I × APPswe) develops an age-related cognitive decline associated with severe amyloidosis, mimicking the pathophysiologic processes in Alzheimer disease (AD). In the quest for biomarkers to monitor, noninvasively, the progression of the disease, we used magnet...

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Bibliographic Details
Main Authors: Markus von Kienlin, Basil Künnecke, Friedrich Metzger, Guido Steiner, J. Grayson Richards, Laurence Ozmen, Helmut Jacobsen, Hansruedi Loetscher
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
Transgenic
PS2APP
Magnetic resonance imaging
Magnetic resonance spectroscopy
N-acetyl-aspartate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002220

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http://www.sciencedirect.com/science/article/pii/S0969996104002220

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