Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element

Objective: Tamoxifen is widely used for inducible Cre-LoxP systems but has several undesirable side effects for researchers investigating metabolism or energy balance, including weight loss, lipoatrophy, and drug incorporation into lipid stores. For this reason, we sought to determine whether a doxy...

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Bibliographic Details
Main Authors: Kenneth T. Lewis, Lily R. Oles, Ormond A. MacDougald
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000709