Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element
Objective: Tamoxifen is widely used for inducible Cre-LoxP systems but has several undesirable side effects for researchers investigating metabolism or energy balance, including weight loss, lipoatrophy, and drug incorporation into lipid stores. For this reason, we sought to determine whether a doxy...
Main Authors: | Kenneth T. Lewis, Lily R. Oles, Ormond A. MacDougald |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-07-01
|
Series: | Molecular Metabolism |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877822000709 |
Similar Items
-
Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSA<sup>mT/mG</sup> Transgenic Mice
by: Prashanth Anamthathmakula, et al.
Published: (2023-08-01) -
A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons
by: Shweta Suiwal, et al.
Published: (2024-02-01) -
A Tet-on and Cre-loxP based genetic engineering system for convenient recycling of selection markers in Penicillium oxalicum
by: Baojie eJiang, et al.
Published: (2016-04-01) -
Unspecific DNA recombination in AdipoqCre-ERT2 – mediated knockout approaches in transgenic mice is sex-, age- and genotype-dependent
by: Andreas Lindhorst, et al.
Published: (2020-01-01) -
Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity
by: Rahul Kumar, et al.
Published: (2022-12-01)