VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear. Recently, the role of voltage‐dependent anion channel protein 1 (VDAC1) in mitochondrial activity and cell apoptosis has attracted much att...

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Bibliographic Details
Main Authors: Xueqin Zhu, Lei Luo, Yanyan Xiong, Nan Jiang, Yurun Wang, Yuan Lv, Ying Xie
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:FEBS Open Bio
Subjects:
4,4'‐diisothiocyanatostilbene‐2,2'‐disulfonic acid
apoptosis
cisplatin
hepatocyte
oligomerization
voltage‐dependent anion channel 1
Online Access:https://doi.org/10.1002/2211-5463.13359

Internet

https://doi.org/10.1002/2211-5463.13359

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