Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

Site-specific protein multi-conjugates are important for both scientific and translational research. Here, the authors genetically encode unnatural amino acids which contain both tetrazine and azide, and use the doubly bio-orthogonal handles to generate bi- and tri-conjugate proteins in high yields.

Bibliographic Details
Main Authors: Yong Wang, Jingming Zhang, Boyang Han, Linzhi Tan, Wenkang Cai, Yuxuan Li, Yeyu Su, Yutong Yu, Xin Wang, Xiaojiang Duan, Haoyu Wang, Xiaomeng Shi, Jing Wang, Xing Yang, Tao Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36658-y

Internet

https://doi.org/10.1038/s41467-023-36658-y

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