LCZ696 Attenuated Doxorubicin-Induced Chronic Cardiomyopathy Through the TLR2-MyD88 Complex Formation

LCZ696 Attenuated Doxorubicin-Induced Chronic Cardiomyopathy Through the TLR2-MyD88 Complex Formation

Background and PurposeThe profibrotic and proinflammatory effects induced by doxorubicin (DOX) are key processes in the development of serious heart damage. Lack of effective drugs and the unclear mechanisms of its side effects limit the clinical treatment of DOX-induced cardiac injury. This study a...

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Bibliographic Details
Main Authors: Shiju Ye, Lan Su, Peiren Shan, Bozhi Ye, Shengjie Wu, Guang Liang, Weijian Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
doxorubicin
LZC696
toll-like receptors
heart failure
molecular target
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.654051/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.654051/full

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