Chemical similarity and biological activities
"Similar molecules exert similar biological activities". Since long, medicinal chemists use this concept to modify the structures of biologically active compounds. Bioisosteric replacements of atoms and groups pave the way from various lead structures to therapeutically useful enzyme inhib...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2002-01-01
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| Series: | Journal of the Brazilian Chemical Society |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600002 |
| _version_ | 1818243066888192000 |
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| author | Kubinyi Hugo |
| author_facet | Kubinyi Hugo |
| author_sort | Kubinyi Hugo |
| collection | DOAJ |
| description | "Similar molecules exert similar biological activities". Since long, medicinal chemists use this concept to modify the structures of biologically active compounds. Bioisosteric replacements of atoms and groups pave the way from various lead structures to therapeutically useful enzyme inhibitors, receptor agonists and antagonists, and other active principles. However, similarity and diversity of chemical structures cannot be defined in an objective manner. Several surprising structure-activity relationships demonstrate that chemically similar compounds may have significantly different biological actions and activities. Some protein ligands exert unexpected new binding modes, after only minor chemical modification. Of course, even optical enantiomers most often have different biological activities. |
| first_indexed | 2024-12-12T13:55:13Z |
| format | Article |
| id | doaj.art-564f5f3ae1a44e2d87d98277c7b78e3f |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-12-12T13:55:13Z |
| publishDate | 2002-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-564f5f3ae1a44e2d87d98277c7b78e3f2022-12-22T00:22:29ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532002-01-01136717726Chemical similarity and biological activitiesKubinyi Hugo"Similar molecules exert similar biological activities". Since long, medicinal chemists use this concept to modify the structures of biologically active compounds. Bioisosteric replacements of atoms and groups pave the way from various lead structures to therapeutically useful enzyme inhibitors, receptor agonists and antagonists, and other active principles. However, similarity and diversity of chemical structures cannot be defined in an objective manner. Several surprising structure-activity relationships demonstrate that chemically similar compounds may have significantly different biological actions and activities. Some protein ligands exert unexpected new binding modes, after only minor chemical modification. Of course, even optical enantiomers most often have different biological activities.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600002chemical similaritysimilarity vs. activitystructure-activity relationshipsagonists and antagonistshydrogen bondsoptical enantiomers |
| spellingShingle | Kubinyi Hugo Chemical similarity and biological activities Journal of the Brazilian Chemical Society chemical similarity similarity vs. activity structure-activity relationships agonists and antagonists hydrogen bonds optical enantiomers |
| title | Chemical similarity and biological activities |
| title_full | Chemical similarity and biological activities |
| title_fullStr | Chemical similarity and biological activities |
| title_full_unstemmed | Chemical similarity and biological activities |
| title_short | Chemical similarity and biological activities |
| title_sort | chemical similarity and biological activities |
| topic | chemical similarity similarity vs. activity structure-activity relationships agonists and antagonists hydrogen bonds optical enantiomers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600002 |
| work_keys_str_mv | AT kubinyihugo chemicalsimilarityandbiologicalactivities |