Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Despite the addition of several new agents to the armamentarium for the treatment of multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and relapsing disease continues to take a great toll, limiting overall survival. Therefore, additional novel approaches are neede...

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Bibliographic Details
Main Authors: Evert Njomen, Allison Vanecek, Theresa A. Lansdell, Ya-Ting Yang, Peter Z. Schall, Christi M. Harris, Matthew P. Bernard, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
multiple myeloma
MYC
proteosome
novel treatment
chemotherapy
protein degradation
Online Access:https://www.mdpi.com/2227-9059/10/5/938

Internet

https://www.mdpi.com/2227-9059/10/5/938

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