Repeated α-GalCer Administration Induces a Type 2 Cytokine-Biased iNKT Cell Response and Exacerbates Atopic Skin Inflammation in Vα14<sup>Tg</sup> NC/Nga Mice

Repeated α-GalCer Administration Induces a Type 2 Cytokine-Biased iNKT Cell Response and Exacerbates Atopic Skin Inflammation in Vα14<sup>Tg</sup> NC/Nga Mice

We have previously shown that Vα14 TCR Tg (Vα14<sup>Tg</sup>) NC/Nga (NC) mice contain increased numbers of double-negative (DN) invariant natural killer T (iNKT) cells that protect against spontaneous development of atopic dermatitis (AD). iNKT cells can regulate immune responses by pro...

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Bibliographic Details
Main Authors: Hyun Jung Park, Tae-Cheol Kim, Yun Hoo Park, Sung Won Lee, Jungmin Jeon, Se-Ho Park, Luc Van Kaer, Seokmann Hong
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
atopic dermatitis
NC/Nga mice
iNKT cells
Vα14 TCR transgenic mice
α-GalCer
Online Access:https://www.mdpi.com/2227-9059/9/11/1619

Internet

https://www.mdpi.com/2227-9059/9/11/1619

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