Novel hemoglobin-derived xanthine oxidase inhibitory peptides: Enzymatic preparation and inhibition mechanisms

Novel hemoglobin-derived xanthine oxidase inhibitory peptides: Enzymatic preparation and inhibition mechanisms

Xanthine oxidase (XO) activity is critical to modulate uric acid and hyperuricemia. Hemoglobin was hydrolyzed by bromelain and the protease from Geobacillus stearothermophilus (GsProS8) to express excellent protein recovery rate (54.87%) and XO inhibitory activity (IC50 of 0.744 mg/mL), resulting fr...

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Bibliographic Details
Main Authors: Peng Zhang, Zhengqiang Jiang, Jia Lei, Qiaojuan Yan, Chang Chang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Functional Foods
Subjects:
Hemoglobin
Enzymatic hydrolysis
Geobacillus stearothermophilus
XO inhibitory peptides
Inhibition type
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623000592

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http://www.sciencedirect.com/science/article/pii/S1756464623000592

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