Low hemagglutinin antigen dose influenza vaccines adjuvanted with AS03 alter the long-term immune responses in BALB/c mice

Low hemagglutinin antigen dose influenza vaccines adjuvanted with AS03 alter the long-term immune responses in BALB/c mice

We investigated the long-term immune profiles of dose-sparing, AS03-adjuvanted vaccines compared to a traditional high-dose, unadjuvated influenza vaccine formulation. BALB/c mice received 2 IM injections of influenza A/Uruguay/716/2007 (H3N2) split vaccine antigen: high-dose (HD) (3 µg hemagglutini...

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Bibliographic Details
Main Authors: Karen K. Yam, Angela Brewer, Virginie Bleau, Édith Beaulieu, Corey P. Mallett, Brian J. Ward
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
adjuvant
antibody-secreting cells
as03
cytokine
chemokine
dose-sparing
hemagglutination inhibition
influenza
long-term immune response
microneutralization
vaccine
Online Access:http://dx.doi.org/10.1080/21645515.2016.1241360

Internet

http://dx.doi.org/10.1080/21645515.2016.1241360

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