SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME

This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde through the glyoxal reaction to produce a series o...

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Bibliographic Details
Main Authors: Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2024-04-01
Series:Química Nova
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422024000700206&lng=pt&tlng=pt

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422024000700206&lng=pt&tlng=pt

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