Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver

Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver

The drug efflux transporter P-glycoprotein (Pgp; ABCB1) plays an important role in drug absorption, disposition, and elimination. There is an ongoing debate whether, in addition to its localization at the plasma membrane, Pgp may also be expressed at the limiting membrane of endolysosomes (ELs), med...

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Bibliographic Details
Main Authors: Birthe Gericke, Inka Wienböker, Gudrun Brandes, Wolfgang Löscher
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
hepatocytes
multidrug transport
lysosomal drug trapping
electron microscopy
early endosomes
Online Access:https://www.mdpi.com/2073-4409/11/9/1556

Internet

https://www.mdpi.com/2073-4409/11/9/1556

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