C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool

C. elegans Notch signaling maintains a pool of germline stem cells within their single-celled mesenchymal niche. Here we investigate the Notch transcriptional response in germline stem cells using single-molecule fluorescence in situ hybridization coupled with automated, high-throughput quantitation...

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Bibliographic Details
Main Authors: ChangHwan Lee, Erika B Sorensen, Tina R Lynch, Judith Kimble
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/18370