Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives

Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives

Triterpene acids, namely, 20,29-dihydrobetulinic acid (BA), ursolic acid (UA) and oleanolic acid (OA) were converted into C-28-amino-functionalized triterpenoids <b>4</b>&#8315;<b>7</b>, <b>8a</b>, <b>15</b>, <b>18</b> and <b>20&l...

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Bibliographic Details
Main Authors: Anna Spivak, Rezeda Khalitova, Darya Nedopekina, Lilya Dzhemileva, Milyausha Yunusbaeva, Victor Odinokov, Vladimir D’yakonov, Usein Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
triterpenoids
betulinic acid
ursolic acid
oleanolic acid
amino group
guanidine group
cytotoxicity
apoptosis
cell cycle
Online Access:https://www.mdpi.com/1420-3049/23/11/3000

Internet

https://www.mdpi.com/1420-3049/23/11/3000

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