Allopregnanolone Promotes Migration and Invasion of Human Glioblastoma Cells through the Protein Tyrosine Kinase c-Src Activation

Allopregnanolone Promotes Migration and Invasion of Human Glioblastoma Cells through the Protein Tyrosine Kinase c-Src Activation

Glioblastomas (GBs) are the most aggressive and common primary malignant brain tumors. Steroid hormone progesterone (P4) and its neuroactive metabolites, such as allopregnanolone (3α-THP) are synthesized by neural, glial, and malignant GB cells. P4 promotes cellular proliferation, migration, and inv...

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Bibliographic Details
Main Authors: Carmen J. Zamora-Sánchez, Claudia Bello-Alvarez, Mauricio Rodríguez-Dorantes, Ignacio Camacho-Arroyo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
allopregnanolone
progesterone
neurosteroid
steroidogenesis
Aldo-keto reductase
c-Src
Online Access:https://www.mdpi.com/1422-0067/23/9/4996

Internet

https://www.mdpi.com/1422-0067/23/9/4996

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