Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Abstract There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics approaches could lead to the identification of novel molecular targets. Here, we perform a genome-wide association study (GWAS) meta-analysis including 14,819 cases among 941,863 participants...

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Dades bibliogràfiques
Autors principals: Sébastien Thériault, Zhonglin Li, Erik Abner, Jian’an Luan, Hasanga D. Manikpurage, Ursula Houessou, Pardis Zamani, Mewen Briend, Estonian Biobank Research Team, Dominique K. Boudreau, Nathalie Gaudreault, Lily Frenette, Déborah Argaud, Manel Dahmene, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, S. Matthijs Boekholdt, Nicholas J. Wareham, Tõnu Esko, Patrick Mathieu, Yohan Bossé
Format: Article
Idioma:English
Publicat: Nature Portfolio 2024-03-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-024-46639-4

Internet

https://doi.org/10.1038/s41467-024-46639-4

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