Structure based design of effective HtpG-derived vaccine antigens against M. tuberculosis

Structure based design of effective HtpG-derived vaccine antigens against M. tuberculosis

Vaccine development against Tuberculosis is a strong need, given the low efficacy of the sole vaccine hitherto used, the Bacillus Calmette–Guérin (BCG) vaccine. The chaperone-like protein HtpGMtb of M. tuberculosis is a large dimeric and multi-domain protein with promising antigenic properties. We h...

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Bibliographic Details
Main Authors: Alessia Ruggiero, Han-Gyu Choi, Giovanni Barra, Flavia Squeglia, Young Woo Back, Hwa-Jung Kim, Rita Berisio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein structure
vaccine
infectious disease
folding
antigen
chaperone
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.964645/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.964645/full

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