Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis--A Pilot Study.

Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis--A Pilot Study.

Preclinical studies show that blocking Interleukin-1 (IL-1) retards the progression of Amyotrophic Lateral Sclerosis (ALS). We assessed the safety of Anakinra (ANA), an IL-1 receptor antagonist, in ALS patients. In a single arm pilot study we treated 17 ALS patients with ANA (100 mg) daily for one y...

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Bibliographic Details
Main Authors: André Maier, Nikolaus Deigendesch, Kathrin Müller, Jochen H Weishaupt, Alexander Krannich, Robert Röhle, Felix Meissner, Kaaweh Molawi, Christoph Münch, Teresa Holm, Robert Meyer, Thomas Meyer, Arturo Zychlinsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4596620?pdf=render

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http://europepmc.org/articles/PMC4596620?pdf=render

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