The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis

The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis

Retinal ischemia is a common pathological event that can result in retinal ganglion cell (RGC) death and irreversible vision loss. The pathogenic mechanisms linking retinal ischemia to RGC loss and visual deficits are uncertain, which has greatly hampered the development of effective treatments. It...

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Bibliographic Details
Main Authors: Yang Deng, Yunzhao Fu, Longxiang Sheng, Yixin Hu, Lishi Su, Jiawen Luo, Chun Yan, Wei Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NLRC5
retinal ischemia–reperfusion injury
pyroptosis
apoptosis
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.669696/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.669696/full

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