A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing

A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing

Abstract Background Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently observed in preclinical animal models of Alzheimer’s disease (AD). This study investigates whether these microscale abnormalities explain characteristic large-scale magnetoencephalography (MEG) activ...

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Bibliographic Details
Main Authors: Anne M. van Nifterick, Alida A. Gouw, Ronald E. van Kesteren, Philip Scheltens, Cornelis J. Stam, Willem de Haan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
MEG
Alzheimer’s disease
Oscillatory slowing
Hyperexcitability
Neural mass models
Neuronal network
Online Access:https://doi.org/10.1186/s13195-022-01041-4

Internet

https://doi.org/10.1186/s13195-022-01041-4

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