Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

The decidualization of endometrial stroma is critical for pregnancy maintenance. Here the authors reveal that Menin ensures the expression of PTX3 through H3K4me3 modification, to balance the BMP and FGF signal in the decidua for normal pregnancy.

Bibliographic Details
Main Authors: Mengying Liu, Wenbo Deng, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang, Zhongxian Lu, Shuangbo Kong
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28657-2

Internet

https://doi.org/10.1038/s41467-022-28657-2

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