Identification of novel genetic variants, including PIM1 and LINC01491, with ICD-10 based diagnosis of pulmonary arterial hypertension in the UK Biobank cohort

Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary vasculature which results in elevations of pulmonary arterial pressures. Here, we conducted a genome-wide association study (GWAS) using the UK Biobank, analyzing the genomes of 493 individuals diagno...

Full description

Bibliographic Details
Main Authors: Alex Pu, Gautam Ramani, Yi-Ju Chen, James A. Perry, Charles C. Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Drug Discovery
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2023.1127736/full