Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease

Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease

The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called multi-target directed ligands (MTDLs) that will...

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Bibliographic Details
Main Authors: Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amiridine
Acetylcholinesterase
Antioxidant capacity
Butyrylcholinesterase
Multi-target directed ligands
NMDA receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222400283X

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http://www.sciencedirect.com/science/article/pii/S075333222400283X

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