Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease

Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease

The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called multi-target directed ligands (MTDLs) that will...

Full description

Bibliographic Details
Main Authors:	Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Amiridine Acetylcholinesterase Antioxidant capacity Butyrylcholinesterase Multi-target directed ligands NMDA receptors
Online Access:	http://www.sciencedirect.com/science/article/pii/S075333222400283X

Similar Items

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: <i>N</i>-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile
by: Galina F. Makhaeva, et al.
Published: (2022-02-01)

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate Receptor Antagonists
by: Jan Konecny, et al.
Published: (2020-12-01)

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy
by: Eva Mezeiova, et al.
Published: (2017-07-01)

Structure-Guided Design of <i>N</i>-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease
by: Barbora Svobodova, et al.
Published: (2023-05-01)

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
by: Abdullah Al Mamun, et al.
Published: (2021-08-01)

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
by: Barbora Svobodova, et al.
Published: (2019-08-01)

7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies
by: Kamil Kuca, et al.
Published: (2013-02-01)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
by: Rafaqat Hussain, et al.
Published: (2022-09-01)

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms
by: Jana Zdarova-Karasova, et al.
Published: (2009-05-01)

Characterization of placental cholinesterases and activity induction associated to environmental organophosphate exposure
by: S. Sánchez, et al.
Published: (2015-01-01)

Cholinesterase-targeting microRNAs identified in silico affect specific biological processes
by: Geula eHanin, et al.
Published: (2011-10-01)

Determination of cholinesterase inhibition potential of rose extract
by: Esra Şentürk, et al.
Published: (2018-10-01)

Cholinesterase inhibitors isolated from bilberry fruit
by: Kamila Borowiec, et al.
Published: (2014-11-01)

Early appearance and possible roles of non-neuromuscular cholinesterases.
by: Carla eFalugi
Published: (2012-04-01)

Reduced Levels of Serum Potassium and Plasma Cholinesterase in Acute Organophosphate Poisoning: Possible Predictive Markers
by: Devanur Prasad
Published: (2014-06-01)

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity
by: Anita Bosak, et al.
Published: (2017-01-01)

Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors
by: Ginson George, et al.
Published: (2022-03-01)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
by: Keith D. Green, et al.
Published: (2018-12-01)

Amaryllidaceae Alkaloids of Belladine-Type from <i>Narcissus pseudonarcissus</i> cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase
by: Abdullah Al Mamun, et al.
Published: (2020-05-01)

A Comprehensive Review of Cholinesterase Modeling and Simulation
by: Danna De Boer, et al.
Published: (2021-04-01)

Association between cholinesterase activity and critical illness brain dysfunction
by: Christopher G. Hughes, et al.
Published: (2022-12-01)

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease
by: Sultan Darvesh, et al.
Published: (2023-12-01)

Cholinesterase Research
by: Jan Korabecny, et al.
Published: (2021-07-01)

Cholinesterases in Tripartite Neuromuscular Synapse
by: Konstantin A. Petrov, et al.
Published: (2021-12-01)

Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs
by: Alicja Skrzypek, et al.
Published: (2022-12-01)

Abstract OR-21: 3D Structure of the Natural Tetrameric Form of Human Butyryl-cholinesterase as Revealed by Cryo-EM, MD and SAXS
by: Konstantin M. Boyko, et al.
Published: (2019-06-01)

Neuroprotective Effects of Blueberries through Inhibition on Cholinesterase, Tyrosinase, Cyclooxygenase-2, and Amyloidogenesis
by: Pari Samani, et al.
Published: (2023-01-01)

Cholinesterase Enzymes Inhibitors from the Leaves of Rauvolfia Reflexa and Their Molecular Docking Study
by: Vikneswaran Murugaiyah, et al.
Published: (2013-03-01)

Assessment of Physicochemical Quality, Antioxidant Content and Activity, and Inhibition of Cholinesterase between Unripe and Ripe Blueberry Fruit
by: Hyesung Hwang, et al.
Published: (2020-05-01)

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease
by: Rosa Purgatorio, et al.
Published: (2021-08-01)

Cholinesterase Inhibitory, Anti-oxidant and Anti-tyrosinase Activities of Three Iranian Species of Dracocephalum
by: Maryam Khodaei, et al.
Published: (2019-07-01)

The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies
by: Muhammad Mansha, et al.
Published: (2021-07-01)

Benzofuran Derivatives from Cortex Mori Radicis and Their Cholinesterase-Inhibitory Activity
by: Xiang Cui, et al.
Published: (2024-01-01)

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice
by: Andrea R. Durrant, et al.
Published: (2012-06-01)

Changes of Cholinesterase Activity in the Erythrocytes, Plasma, Diaphragm, Liver and Various Parts of the Brain in the Rabbit Following Transfusion of Erythrocytes with Soman Inhibited Acetylcholinesterase
by: Jiří Kassa, et al.
Published: (1997-01-01)

Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors
by: Martin Krátký, et al.
Published: (2021-11-01)

Extraction of Antioxidants from Winemaking Byproducts: Effect of the Solvent on Phenolic Composition, Antioxidant and Anti-Cholinesterase Activities, and Electrochemical Behaviour
by: María José Jara-Palacios, et al.
Published: (2020-07-01)

Wide awake under anesthesia: Scoline apnoea update
by: Marković Danica, et al.
Published: (2016-01-01)

In vitro and in silico analysis of Solanum torvum fruit and methyl caffeate interaction with cholinesterases
by: Maha Aljabri, et al.
Published: (2023-10-01)

In vivo cholinesterase sensitivity of gilthead seabream (Sparus aurata) exposed to organophosphate compounds: Influence of biological factors
by: M.G. Albendín, et al.
Published: (2021-02-01)