Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine (DA) neurons. These pathological featu...

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Bibliographic Details
Main Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Subjects:
PLX3397
Neuroinflammation
Parkinson’s disease
Synucleinopathy
Major-histocompatibility complex-II
Neurodegeneration
Online Access:https://doi.org/10.1186/s12974-024-03108-5

Internet

https://doi.org/10.1186/s12974-024-03108-5

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