γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

Abstract Background γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subtle differences in PS1- and PS2-mediated cleavages o...

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Bibliographic Details
Main Authors: Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde, Yong Ran
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Presenilin
Gene knockout
γ-Secretase modulators (GSMs)
Amyloid peptide
Amyloid protein precursor (APP)
NOTCH
Online Access:http://link.springer.com/article/10.1186/s13195-020-00622-5

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http://link.springer.com/article/10.1186/s13195-020-00622-5

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