Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53

Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53

Abstract Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by radiation and/or chemotherapeutic drugs. These genotoxic treatments eliminate host hematopoietic precursors by inducing p53-mediated apoptos...

Full description

Bibliographic Details
Main Authors: Natalia Fedtsova, Elena A. Komarova, Kellee F. Greene, Liliya R. Novototskaya, Ivan Molodtsov, Craig M. Brackett, Evguenia Strom, Anatoli S. Gleiberman, Alexander N. Shakhov, Andrei V. Gudkov
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03824-3

Internet

https://doi.org/10.1038/s41419-021-03824-3

Similar Items