Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner

Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner

ObjectiveIn a recent study, we found an elevated level of interleukin 8 (IL-8) in response to bacterial incubation in thrombin-sufficient human whole blood anticoagulated by the fibrin polymerization blocking peptide GPRP. Whether thrombin directly activated leukocytes or mediated the release via th...

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Bibliographic Details
Main Authors: Huy Quang Quach, Christina Johnson, Karin Ekholt, Rakibul Islam, Tom Eirik Mollnes, Per H. Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
platelets
IL-8
acute inflammation
human whole blood
thrombin
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.865386/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.865386/full

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