ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

Abstract Background Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to...

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Bibliographic Details
Main Authors: Qiushi Lin, Xuesong Chen, Fanzheng Meng, Kosuke Ogawa, Min Li, Ruipeng Song, Shugeng Zhang, Ziran Zhang, Xianglu Kong, Qinggang Xu, Fuliang He, Xuewei Bai, Bei Sun, Mien-Chie Hung, Lianxin Liu, Jack Wands, Xiaoqun Dong
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Cancer
Subjects:
Aspartate β-hydroxylase (ASPH)
Exosome
Notch
Metastasis
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12943-019-1077-0

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http://link.springer.com/article/10.1186/s12943-019-1077-0

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