An Orthotopic Model of Glioblastoma Is Resistant to Radiodynamic Therapy with 5-AminoLevulinic Acid

An Orthotopic Model of Glioblastoma Is Resistant to Radiodynamic Therapy with 5-AminoLevulinic Acid

Radiosensitization of glioblastoma is a major ambition to increase the survival of this incurable cancer. The 5-aminolevulinic acid (5-ALA) is metabolized by the heme biosynthesis pathway. 5-ALA overload leads to the accumulation of the intermediate fluorescent metabolite protoporphyrin IX (PpIX) wi...

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Bibliographic Details
Main Authors: Charles Dupin, Jade Sutter, Samuel Amintas, Marie-Alix Derieppe, Magalie Lalanne, Soule Coulibaly, Joris Guyon, Thomas Daubon, Julian Boutin, Jean-Marc Blouin, Emmanuel Richard, François Moreau-Gaudry, Aurélie Bedel, Véronique Vendrely, Sandrine Dabernat
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
glioblastoma
radiotherapy
5-AminoLevulinic Acid (5-ALA)
protoporphyrin IX
radiodynamic therapy
Online Access:https://www.mdpi.com/2072-6694/14/17/4244

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https://www.mdpi.com/2072-6694/14/17/4244

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