Comparison of platelets characteristics according to various processing methods
To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphologica...
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Format: | Article |
Language: | Russian |
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ABV-press
2015-01-01
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Series: | Онкогематология |
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Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/130 |
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author | O. V. Karpova I. V. Obraztsov P. E. Trakhtman A. A. Ignatova1 M. A. Panteleev S. A. Rumyantsev |
author_facet | O. V. Karpova I. V. Obraztsov P. E. Trakhtman A. A. Ignatova1 M. A. Panteleev S. A. Rumyantsev |
author_sort | O. V. Karpova |
collection | DOAJ |
description | To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy. |
first_indexed | 2024-04-09T20:25:23Z |
format | Article |
id | doaj.art-568477e6e43d474989ffe9dc93adb2dd |
institution | Directory Open Access Journal |
issn | 1818-8346 2413-4023 |
language | Russian |
last_indexed | 2024-04-09T20:25:23Z |
publishDate | 2015-01-01 |
publisher | ABV-press |
record_format | Article |
series | Онкогематология |
spelling | doaj.art-568477e6e43d474989ffe9dc93adb2dd2023-03-30T20:15:10ZrusABV-pressОнкогематология1818-83462413-40232015-01-0194374510.17650/1818-8346-2014-9-4-37-45145Comparison of platelets characteristics according to various processing methodsO. V. Karpova0I. V. Obraztsov1P. E. Trakhtman2A. A. Ignatova13M. A. Panteleev4S. A. Rumyantsev5Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow; 4, Kosygina st., Moscow, Russia, 119991 M.V. Lomonosov Moscow State University; 1, Leninskie gory, Moscow, Russia, 119991Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 1, Ostrovityanova st., Moscow, Russia, 117997 Moscow Institute of Physics and Technology State University; 9, Institutskiy per., Dolgoprudnyi, Moscow Oblast, Russia, 141700To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy.https://oncohematology.abvpress.ru/ongm/article/view/130platelet concentrateplatelet storage solutionplasmapathogen inactivationriboflavinultraviolet |
spellingShingle | O. V. Karpova I. V. Obraztsov P. E. Trakhtman A. A. Ignatova1 M. A. Panteleev S. A. Rumyantsev Comparison of platelets characteristics according to various processing methods Онкогематология platelet concentrate platelet storage solution plasma pathogen inactivation riboflavin ultraviolet |
title | Comparison of platelets characteristics according to various processing methods |
title_full | Comparison of platelets characteristics according to various processing methods |
title_fullStr | Comparison of platelets characteristics according to various processing methods |
title_full_unstemmed | Comparison of platelets characteristics according to various processing methods |
title_short | Comparison of platelets characteristics according to various processing methods |
title_sort | comparison of platelets characteristics according to various processing methods |
topic | platelet concentrate platelet storage solution plasma pathogen inactivation riboflavin ultraviolet |
url | https://oncohematology.abvpress.ru/ongm/article/view/130 |
work_keys_str_mv | AT ovkarpova comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods AT ivobraztsov comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods AT petrakhtman comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods AT aaignatova1 comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods AT mapanteleev comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods AT sarumyantsev comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods |