Comparison of platelets characteristics according to various processing methods

To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphologica...

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Main Authors: O. V. Karpova, I. V. Obraztsov, P. E. Trakhtman, A. A. Ignatova1, M. A. Panteleev, S. A. Rumyantsev
Format: Article
Language:Russian
Published: ABV-press 2015-01-01
Series:Онкогематология
Subjects:
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/130
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author O. V. Karpova
I. V. Obraztsov
P. E. Trakhtman
A. A. Ignatova1
M. A. Panteleev
S. A. Rumyantsev
author_facet O. V. Karpova
I. V. Obraztsov
P. E. Trakhtman
A. A. Ignatova1
M. A. Panteleev
S. A. Rumyantsev
author_sort O. V. Karpova
collection DOAJ
description To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy.
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spelling doaj.art-568477e6e43d474989ffe9dc93adb2dd2023-03-30T20:15:10ZrusABV-pressОнкогематология1818-83462413-40232015-01-0194374510.17650/1818-8346-2014-9-4-37-45145Comparison of platelets characteristics according to various processing methodsO. V. Karpova0I. V. Obraztsov1P. E. Trakhtman2A. A. Ignatova13M. A. Panteleev4S. A. Rumyantsev5Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow; 4, Kosygina st., Moscow, Russia, 119991 M.V. Lomonosov Moscow State University; 1, Leninskie gory, Moscow, Russia, 119991Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 1, Ostrovityanova st., Moscow, Russia, 117997 Moscow Institute of Physics and Technology State University; 9, Institutskiy per., Dolgoprudnyi, Moscow Oblast, Russia, 141700To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy.https://oncohematology.abvpress.ru/ongm/article/view/130platelet concentrateplatelet storage solutionplasmapathogen inactivationriboflavinultraviolet
spellingShingle O. V. Karpova
I. V. Obraztsov
P. E. Trakhtman
A. A. Ignatova1
M. A. Panteleev
S. A. Rumyantsev
Comparison of platelets characteristics according to various processing methods
Онкогематология
platelet concentrate
platelet storage solution
plasma
pathogen inactivation
riboflavin
ultraviolet
title Comparison of platelets characteristics according to various processing methods
title_full Comparison of platelets characteristics according to various processing methods
title_fullStr Comparison of platelets characteristics according to various processing methods
title_full_unstemmed Comparison of platelets characteristics according to various processing methods
title_short Comparison of platelets characteristics according to various processing methods
title_sort comparison of platelets characteristics according to various processing methods
topic platelet concentrate
platelet storage solution
plasma
pathogen inactivation
riboflavin
ultraviolet
url https://oncohematology.abvpress.ru/ongm/article/view/130
work_keys_str_mv AT ovkarpova comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods
AT ivobraztsov comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods
AT petrakhtman comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods
AT aaignatova1 comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods
AT mapanteleev comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods
AT sarumyantsev comparisonofplateletscharacteristicsaccordingtovariousprocessingmethods