The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons

Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and selectivity of NGF binding, however, whether interacti...

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Bibliographic Details
Main Authors: Juan P. Zanin, Laura E. Montroull, Marta Volosin, Wilma J. Friedman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00485/full