Store-Operated Ca<sup>2+</sup> Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy

Store-Operated Ca<sup>2+</sup> Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder that may lead patients to sudden cell death through the occurrence of ventricular arrhythmias. ACM is characterised by the progressive substitution of cardiomyocytes with fibrofatty scar tissue that predisposes the heart to life-threatening a...

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Bibliographic Details
Main Authors: Francesco Moccia, Valentina Brunetti, Teresa Soda, Pawan Faris, Giorgia Scarpellino, Roberto Berra-Romani
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Journal of Clinical Medicine
Subjects:
flecainide
arrhythmogenic cardiomyopathy
cardiac mesenchymal stromal cells
fibro-adipogenic differentiation
Ca<sup>2+</sup> oscillations
store-operated Ca<sup>2+</sup> entry
Online Access:https://www.mdpi.com/2077-0383/12/16/5295

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https://www.mdpi.com/2077-0383/12/16/5295

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