Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation, however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse macrophages reveals that pro-inflammatory paused genes, activated via global negative elongation factor (NELF) dissociation and R...

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Bibliographic Details
Main Authors: Maria A Sacta, Bowranigan Tharmalingam, Maddalena Coppo, David A Rollins, Dinesh K Deochand, Bradley Benjamin, Li Yu, Bin Zhang, Xiaoyu Hu, Rong Li, Yurii Chinenov, Inez Rogatsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
inflammation
macrophages
glucocorticoid receptor
transcriptional repression
transcription initiation and elongation
RNA Polymerase 2
Online Access:https://elifesciences.org/articles/34864

Internet

https://elifesciences.org/articles/34864

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