Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation, however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse macrophages reveals that pro-inflammatory paused genes, activated via global negative elongation factor (NELF) dissociation and R...
Main Authors: | Maria A Sacta, Bowranigan Tharmalingam, Maddalena Coppo, David A Rollins, Dinesh K Deochand, Bradley Benjamin, Li Yu, Bin Zhang, Xiaoyu Hu, Rong Li, Yurii Chinenov, Inez Rogatsky |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/34864 |
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