Actin polymerization regulates glycoprotein Ibα shedding

Actin polymerization regulates glycoprotein Ibα shedding

Glycoprotein (GP) Ibα shedding mediated by ADAM17 (a disintegrin and metalloproteinase 17) plays an important role in negatively regulating platelet function and thrombus formation. However, the mechanism of GPIbα shedding remains elusive. Here, we show that jasplakinolide (an actin-polymerizing pep...

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Bibliographic Details
Main Authors: Kangxi Zhou, Yue Xia, Mengnan Yang, Weiling Xiao, Lili Zhao, Renping Hu, Khan Muhammad Shoaib, Rong Yan, Kesheng Dai
Format: Article
Language:English
Published: Taylor & Francis Group 2022-04-01
Series:Platelets
Subjects:
actin polymerization
calpain
filamin a
gpibα shedding
platelet
Online Access:http://dx.doi.org/10.1080/09537104.2021.1922882

Internet

http://dx.doi.org/10.1080/09537104.2021.1922882

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