Enhanced Biosafety of the <i>Sleeping Beauty</i> Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells

Enhanced Biosafety of the <i>Sleeping Beauty</i> Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells

Neovascular age-related macular degeneration (nvAMD) is characterized by choroidal neovascularization (CNV), which leads to retinal pigment epithelial (RPE) cell and photoreceptor degeneration and blindness if untreated. Since blood vessel growth is mediated by endothelial cell growth factors, inclu...

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Bibliographic Details
Main Authors: Nina Harmening, Sandra Johnen, Zsuzsanna Izsvák, Zoltan Ivics, Martina Kropp, Thais Bascuas, Peter Walter, Andreas Kreis, Bojan Pajic, Gabriele Thumann
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
nvAMD
PEDF
RPE cells
gene therapy
non-viral
<i>Sleeping Beauty</i> transposase
Online Access:https://www.mdpi.com/2218-273X/13/4/658

Internet

https://www.mdpi.com/2218-273X/13/4/658

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