Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane

Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane

The autoimmune dermatosis pemphigus foliaceus (PF) is predominantly caused by IgG autoantibodies against the desmosomal cadherin desmoglein (Dsg) 1. The exact mechanisms that lead to the characteristic epidermal blistering are not yet fully understood. In the present study, we used a variety of biop...

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Bibliographic Details
Main Authors: Matthias Hiermaier, Daniela Kugelmann, Mariya Y. Radeva, Dario Didona, Kamran Ghoreschi, Solimani Farzan, Michael Hertl, Jens Waschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
pemphigus
signaling / signaling pathways
localization
desmoglein (Dsg)
Stimulated Emission Depletion (STED)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.882116/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.882116/full

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