The antioxidant effect of preischemic dexmedetomidine in a rat model: increased expression of Nrf2/HO-1 via the PKC pathway

The antioxidant effect of preischemic dexmedetomidine in a rat model: increased expression of Nrf2/HO-1 via the PKC pathway

Background: The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated. Activation of Nuclear factor erythroid 2-related factor (Nrf2) and Heme Oxygenase-1 (HO-1) represents a major antioxidant-defens...

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Bibliographic Details
Main Authors: Yong-Hee Park, Hee-Pyoung Park, Eugene Kim, Hannah Lee, Jung-Won Hwang, Young-Tae Jeon, Young-Jin Lim
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Brazilian Journal of Anesthesiology
Subjects:
Antioxidant
Cerebral ischemia
Dexmedetomidine
Nuclear factor erythroid 2-related factor
Protein kinase C
Online Access:http://www.sciencedirect.com/science/article/pii/S0104001421003316

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http://www.sciencedirect.com/science/article/pii/S0104001421003316

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