Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Abstract Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABAA subunits promote misfolding and inefficient assembly of th...

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Bibliographic Details
Main Authors: Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell & Bioscience
Online Access:https://doi.org/10.1186/s13578-022-00783-w

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https://doi.org/10.1186/s13578-022-00783-w

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