Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors
Abstract Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABAA subunits promote misfolding and inefficient assembly of th...
Main Authors: | Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2022-04-01
|
Series: | Cell & Bioscience |
Online Access: | https://doi.org/10.1186/s13578-022-00783-w |
Similar Items
-
ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors
by: Jaleh S. Mesgarzadeh, et al.
Published: (2022-05-01) -
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
by: Ryan Paxman, et al.
Published: (2018-08-01) -
Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli
by: Dezerae Cox, et al.
Published: (2022-11-01) -
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis
by: Erik A. Blackwood, et al.
Published: (2020-03-01) -
GABAA receptors: structure, function, pharmacology, and related disorders
by: Amr Ghit, et al.
Published: (2021-08-01)