Development and Validation of a UHPLC–MS/MS-Based Method to Quantify Cenobamate in Human Plasma Samples

Development and Validation of a UHPLC–MS/MS-Based Method to Quantify Cenobamate in Human Plasma Samples

Cenobamate (CNB) is the newest antiseizure medication (ASM) approved by the FDA in 2019 to reduce uncontrolled partial-onset seizures in adult patients. Marketed as Xcopri in the USA or Ontozry in the EU (tablets), its mechanism of action has not been fully understood yet; however, it is known that...

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Bibliographic Details
Main Authors: Bruno Charlier, Albino Coglianese, Francesca Felicia Operto, Giangennaro Coppola, Ugo de Grazia, Pierantonio Menna, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
antiseizure medications
UHPLC–MS/MS
liquid chromatography
mass spectrometry
cenobamate
therapeutic drug monitoring
Online Access:https://www.mdpi.com/1420-3049/27/21/7325

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https://www.mdpi.com/1420-3049/27/21/7325

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