Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

Abstract Immune checkpoint blockade (ICB) is an attractive option in cancer therapy, but its efficacy is still less than expected due to the transient and incomplete blocking and the low responsiveness. Herein, an unprecedented programmable unlocking nano‐matryoshka‐CRISPR system (PUN) targeting pro...

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Bibliographic Details
Main Authors: Jin Yang, Zhike Li, Meiling Shen, Yan Wang, Li Wang, Jiamiao Li, Wen Yang, Jie Li, Haijun Li, Xinxin Wang, Qinjie Wu, Changyang Gong
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Advanced Science
Subjects:
cancer immunotherapy
cascade amplified
CRISPR/Cas9
nano‐matryoshka
programmable unlocking
Online Access:https://doi.org/10.1002/advs.202100292

Internet

https://doi.org/10.1002/advs.202100292

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